Coronary artery disease (CAD) is the most common type of heart disease. It happens when the arteries that supply blood to heart muscle become hardened and narrowed due to the buildup of cholesterol and other material, called plaque. This can lead to chest pain (angina) or a heart attack - also known as acute coronary syndromes.
A study on the cardiac safety of nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) found that genetic variability may contribute to the susceptibility for acute coronary syndromes observed in some NSAID users. In particular, genetic polymorphisms in the PTGS1 and CRP genes appear to be candidates for a possible gene-drug interaction influencing the acute coronary risk associated with NSAID use.
Related to:
coronary artery disease, CAD, heart attack, unstable angina, myocardial infarction