Carbamazepine is used for treating seizures as well as nerve pain and bipolar disorder. It may cause life-threatening allergic reactions like Stevens-Johnson syndrome (SJS) or Toxic epidermal necrolysis (TEN). Symptoms include: facial swelling, tongue swelling, hives, a red or purple skin rash that spreads within hours to days and blisters on the skin or mucous membranes.
Carbamazepine hypersensitivity is immune-mediated, although factors determining its occurrence and severity are unknown.1 The TNF2 allele has been associated with severe carbamazepine hypersensitivity reactions.1
Related to:
Carbamazepine, Tegretol, Carbatrol, Equetro, Epitol, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)